Pharma Industrial India Magazine - July - August 2024

Q Tell us about the key portfolio of TA Instruments that is centered around the pharmaceutical industry and what differentiates these products from its competitors? Calliste Scholl: TA Instruments, a divi- sion of Waters Corporation, is a global leader in manufacturing cutting-edge systems for thermal analysis, rheology, microcalorimetry, and mechanical analy- sis. These instruments play pivotal roles in small molecule and biological drug characterization in pharmaceutical re- search and development across various stages, from late discovery to manufac- turing. Our instrumentation is used to tackle the following industry challenges: • Drug-Target Binding: TA Instru- ments™ Isothermal Titration Calorime- ters (ITC) help researchers characterize binding interactions to ensure drug can- didates are selected with high specificity and minimal unwanted side effects. • API Stability and Interaction: Differ- ential scanning calorimetry (DSC) is used to assess API stability, detect the presence of polymorphs and evaluate in- teractions with excipients. Isothermal mi- crocalorimetry can also be used to guide formulation development of complex samples via the direct measurement of the formulations’ thermal activity. • Oxidation Assessment: Thermograv- imetric analysis (TGA) is used to detect oxidative degradation, for API stability studies. • Water Sorption: Sorption analysis (SA) is used to characterize water sorp- tion behavior, addressing hygroscopicity concerns. • Texture Evaluation: Rheology is used to study cream texture, ensuring desir- able product characteristics. • Powder Flow: Rheology is also used to assess powder flow properties to help design and prevent hopper clogging. Calliste Scholl PhD, Segment Marketing Manager Life Sciences, TA Instruments Division, Waters Corporation PHARMA INDUSTRIALINDIA · JUL-AUG 24 16 INTEEWRSVIEW Our cutting-edge TA Instruments RS-DSC is a high-throughput system specifically designed for biologic drug development, says Calliste Scholl, PhD, Segment Marketing Manager – Life Sciences, TA Instruments Division, Waters Corporation in her recent interaction with Pharma Industrial India.