Amylyx Pharmaceuticals has appointed Dan Monahan as Chief Commercial Officer.

Monahan will also join the company’s leadership team. Monahan joined Amylyx in January 2024, bringing more than 20 years of commercial leadership experience in the biopharmaceutical industry overseeing sales, marketing, and market access for multiple product lines.

“We are excited to announce the appointment of Dan Monahan to Chief Commercial Officer as Amylyx prepares for the first participant dosed in the Phase 3 LUCIDITY clinical trial of avexitide for the treatment of post-bariatric hypoglycemia planned in the first quarter of 2025. Dan has a strong track record of launching medicines and excels in building and leading high-performing teams that have brought new medicines to communities with high unmet needs,” said Joshua Cohen and Justin Klee, Co-CEOs of Amylyx.

“Since joining Amylyx earlier this year, Monahan has demonstrated invaluable leadership as we work towards ensuring launch readiness for the avexitide program ahead of Phase 3 data expected in 2026 and potential future launches. We are confident that the addition of Mr. Monahan to our leadership team will play a crucial role in delivering a meaningful impact to the PBH community as we continue to move forward in our goal for avexitide to be the first therapy approved for people living with PBH,” Joshua Cohen and Justin Klee added.

Throughout his career, Monahan has remained deeply committed to launching therapies that address high unmet medical needs, bringing critical treatments to those who need them most. Prior to joining Amylyx, Monahan served as Vice President, Head of CNS Marketing and Portfolio Strategy at Otsuka Pharmaceuticals, where he led the US commercialization efforts for the company’s CNS franchise, including REXULTI® and ABILIFY MAINTENA®, which played a critical role in treating serious mental health conditions.

Before joining Otsuka, Monahan held senior leadership roles at Novartis. He led the commercial execution of the company’s flagship blockbuster dermatology brand, COSENTYX®, for patients with autoimmune conditions. Prior to Novartis, Mr. Monahan spent 14 years at Sanofi in positions of increasing leadership responsibility across sales, marketing and market access. He received an MBA from Seton Hall University, and is a graduate of the United States Military Academy at West Point. Dan served as a Field Artillery Officer in the US Army.

“I look forward to continuing to collaborate with the team on advancing novel therapies from development through commercialization, with our first focus on avexitide for the potential treatment of post-bariatric hypoglycemia,” said Dan Monahan, Chief Commercial Officer of Amylyx.

“Since joining Amylyx, I have seen first-hand both the resilience of those with post-bariatric hypoglycemia and the significant quality of life impacts that this debilitating condition can have. I am deeply motivated by the opportunity to support people living with PBH and potentially addressing the critical unmet need for a treatment option,” added Monahan.

In this role, Monahan will lead the company’s commercialization efforts, particularly as Amylyx prepares for the potential approval of avexitide, an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist for the treatment of post-bariatric hypoglycemia (PBH). Amylyx plans to initiate LUCIDITY, a multicenter, randomized, double-blind, placebo-controlled Phase 3 clinical trial designed to evaluate the efficacy and safety of avexitide in participants with PBH in the first quarter of 2025.