Syntax Bio has announced a research and development collaboration with Mayo Clinic focused on advancing stem cell-derived pancreatic cell therapies for Type 1 Diabetes (T1D).

Under the collaboration, the teams seek to define and develop an allogeneic pancreatic beta cell therapy for insulin-dependent diabetes based on patient needs. Syntax Bio plans to use its proprietary CellgorithmTM platform to guide induced pluripotent stem cells into beta cells. Mayo Clinic will provide expertise in pancreatic biology and functional testing in preclinical diabetes models to support regulatory-enabling studies and early clinical development.

John Craighead, Chief Executive Officer (CEO), Syntax Bio, said, “The collaboration reflects our belief that regenerative medicine must start with precise control over cell identity and function. By combining our Cellgorithm platform with Mayo Clinic’s translational and clinical expertise, we aim to accelerate the development of a next-generation cell therapy with transformative real-world benefits for patients with Type 1 Diabetes.”

The collaboration is focused on solving practical challenges in developing pancreatic cell therapies, including making sure the cells are the right type, function properly, can be produced consistently, and can be manufactured at scale.

The teams will work in rapid development cycles, using results from functional testing to improve cell identity, maturity and performance. Programs that meet development milestones may advance through biopharmaceutical partnerships or other pathways to support further development and potential clinical testing.

Cellgorithm technology simplifies stem cell differentiation by programming the sequence of gene activations needed to create specific cell types. The platform reduces the need for repeated manual interventions and has demonstrated the ability to generate target cell types in days or weeks rather than months.

This collaboration follows Syntax Bio’s recent grant award from Breakthrough T1D to advance pancreatic beta cell therapy for type 1 diabetes.