Tiziana Life Sciences has announced a product development services agreement with Renaissance Lakewood, a Contract Development and Manufacturing Organization (CDMO) focused on nasal drug delivery.

This collaboration aims to optimize the current formulation and develop a comprehensive plan for the scale-up of foralumab in a nasal device. Intranasal foralumab is currently under development for treating neurodegenerative and inflammatory diseases or conditions.

Under this agreement, Renaissance will use its extensive expertise in pharmaceutical-nasal product development and manufacturing to support the production of intranasal foralumab, ensuring compliance with the highest quality and regulatory requirements. This collaboration is a critical step in Tiziana's strategy to expedite clinical development and potential commercialization of intranasal foralumab.

Intranasal foralumab offers a novel therapeutic approach by modulating the immune system to reduce neuroinflammation, a key factor in the progression of diseases such as Alzheimer's disease and multiple sclerosis. Recent studies have demonstrated its potential to activate regulatory T cells that cross the blood-brain barrier, dampening microglial activation and providing therapeutic benefits to patients.

Ivor Elrifi, CEO of Tiziana Life Sciences, commented, “Partnering with Renaissance is a significant milestone in our mission to bring intranasal foralumab to patients in need. Their proven track record in pharmaceutical manufacturing will be invaluable as we advance our clinical programs and prepare for potential market entry.”

This collaboration aligns with Tiziana's commitment to addressing unmet medical needs through innovative therapies. It represents a pivotal advancement in the Company's efforts to deliver effective treatments for debilitating neurodegenerative and inflammatory conditions.